ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GSK3B

Full Name:

glycogen synthase kinase 3 beta

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3q13.3

Physical Location:

121028232-121295202 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 56637 Rat: 84027 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GSK3B

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002093.2	NP_002084.2	NC_000003.10 range: 121028232..121295202, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030877	beta-catenin destruction complex	Cellular Component	IDA (9601641\|16188939)
GO:0005829	cytosol	Cellular Component	EXP (8524413\|11955436\|12000790\|12820959\|15327769\|16753179)
GO:0005737	cytoplasm	Cellular Component	IDA (14744935)
GO:0005634	nucleus	Cellular Component	IDA (14744935)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	IDA (14744935)
GO:0002039	p53 binding	Molecular Function	IDA (14744935)
GO:0051059	NF-kappaB binding	Molecular Function	IPI (15465828)
GO:0050321	tau-protein kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0046827	positive regulation of protein export from nucleus	Biological Process	IDA (14744935)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (14744935)
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA (11104755\|14744935)
GO:0007242	intracellular signaling cascade	Biological Process	IDA (14749367)
GO:0006983	ER overload response	Biological Process	IDA (14744935)
GO:0005977	glycogen metabolic process	Biological Process	TAS (7980435)
GO:0060070	Wnt receptor signaling pathway through beta-catenin	Biological Process	IC (9601641)