ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

84027

Symbol:

Gsk3b

Full Name:

glycogen synthase kinase 3 beta

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

11q21

Physical Location:

64284730-64428697 on NC_005110.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2932 Symbol (Name): GSK3B (glycogen synthase kinase 3 beta)

Ortholog Status:

The human GeneID 2932 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gsk3b
Fold Change:		-1.13
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_032080.1	NP_114469.1	NC_005110.2 range: 64284730..64428697, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0043234	protein complex	Cellular Component	IDA (17329210)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0045121	membrane raft	Cellular Component	IDA (16735023)
GO:0005737	cytoplasm	Cellular Component	TAS (15073173)
GO:0005829	cytosol	Cellular Component	IDA (17329210)
GO:0005829	cytosol	Cellular Component	ISS
GO:0043227	membrane-bounded organelle	Cellular Component	ISS
GO:0043198	dendritic shaft	Cellular Component	ISS
GO:0043197	dendritic spine	Cellular Component	IDA (17329210)
GO:0030877	beta-catenin destruction complex	Cellular Component	ISS
GO:0030877	beta-catenin destruction complex	Cellular Component	IEA
GO:0030426	growth cone	Cellular Component	ISS
GO:0043025	cell soma	Cellular Component	ISS
GO:0019901	protein kinase binding	Molecular Function	IPI (16478782)
GO:0051059	NF-kappaB binding	Molecular Function	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0035255	ionotropic glutamate receptor binding	Molecular Function	IPI (17329210)
GO:0048156	tau protein binding	Molecular Function	IDA (16735023)
GO:0008013	beta-catenin binding	Molecular Function	ISS
GO:0050321	tau-protein kinase activity	Molecular Function	IDA (16735023)
GO:0050321	tau-protein kinase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (12610628)
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	TAS (2164470)
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	ISS
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	IEA
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	IDA (12808104\|17329210)
GO:0004672	protein kinase activity	Molecular Function	ISS
GO:0002039	p53 binding	Molecular Function	ISS
GO:0002039	p53 binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IDA (17329210)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0050321	tau-protein kinase activity	Molecular Function	ISS
GO:0051059	NF-kappaB binding	Molecular Function	IEA
GO:0048168	regulation of neuronal synaptic plasticity	Biological Process	IMP (17329210)
GO:0046827	positive regulation of protein export from nucleus	Biological Process	ISS
GO:0046827	positive regulation of protein export from nucleus	Biological Process	IEA
GO:0043066	negative regulation of apoptosis	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (12808104)
GO:0045444	fat cell differentiation	Biological Process	ISS
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0030010	establishment of cell polarity	Biological Process	IDA (12610628)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (17329210)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006611	protein export from nucleus	Biological Process	ISS
GO:0006916	anti-apoptosis	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	TAS (12393899)
GO:0006950	response to stress	Biological Process	ISS
GO:0006983	ER overload response	Biological Process	IEA
GO:0006983	ER overload response	Biological Process	ISS
GO:0007163	establishment and/or maintenance of cell polarity	Biological Process	IDA (12610628)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	IDA (12808104)
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0016055	Wnt receptor signaling pathway	Biological Process	ISS
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IEA
GO:0018105	peptidyl-serine phosphorylation	Biological Process	ISS
GO:0000320	re-entry into mitotic cell cycle	Biological Process	ISS