ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rnf14

Full Name:

ring finger protein 14

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 B3|18 17.0 cM

Physical Location:

38456342-38477456 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9604 Symbol (Name): RNF14 (ring finger protein 14)

Ortholog Status:

The human GeneID 9604 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rnf14
Original ID2:		AW123517

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020012.1	NP_064396.1	NC_000084.5 range: 38456342..38477456

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS (11322894)
GO:0005737	cytoplasm	Cellular Component	ISS (11322894)
GO:0005515	protein binding	Molecular Function	ISS (10085091)
GO:0019787	small conjugating protein ligase activity	Molecular Function	ISS (11322894)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA