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Gene Information
Gene ID:5690
Full Name:proteasome (prosome, macropain) subunit, beta type, 2
Organism:Homo sapiens (Human)
Genetic Location:1p34.2
Physical Location:35841325-35879729 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:BQ050102
Fold Change:0.68
P Value:5.00E-03
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Information
Original ID1:Hs.471441
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002794.3NP_002785.1NC_000001.9 range: 35841325..35879729, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentIEA
GO:0005839proteasome core complexCellular ComponentIEA
GO:0004298threonine endopeptidase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (15029244)
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processBiological ProcessEXP (11285280)
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (12791267)
Other Database Cross Links
NCBI Entrez Gene:5690
HuGE Navigator:5690