| Gene Information |
| Gene ID: | | 56907 |
| Symbol: | | SPIRE1 |
| Full Name: | | spire homolog 1 (Drosophila) |
| Alias: | | MGC150621|MGC150622|Spir-1 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 18 |
| Genetic Location: | | 18p11.21 |
| Physical Location: | | 12436510-12647911 on NC_000018.8, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Hs.515283 | | Note: | | "Class II, down-regulated gene" |
| | Dataset Information | | Name: | | 16292326 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed | | Summary: | | In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D18S53 | | | 11482730 | | Region: | | 9482730-13482730 | | Phenotype: | | Alcoholism phenotype along with age, gender, and P300 or constraint | | Name: | | 15211641 | | Method: | | Linkage | | Publication: | | Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed | | Summary: | | A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb). |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0005856 | cytoskeleton | Cellular Component | IEA | |
| GO:0003779 | actin binding | Molecular Function | IEA | |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | |
| GO:0006810 | transport | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 56907 |
| HGNC: | | 30622 |
| Ensembl: | | ENSG00000134278 |
| MIM: | | 609216 |
| HPRD: | | 11600 |
| HuGE Navigator: | | 56907 |
| dbSNP: | | SPIRE1 |
| GeneCard: | | SPIRE1 |
| AceView: | | SPIRE1 |
