ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

5728

Symbol:

PTEN

Full Name:

phosphatase and tensin homolog (mutated in multiple advanced cancers 1)

Alias:

BZS|MGC11227|MHAM|MMAC1|PTEN1|TEP1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q23.3

Physical Location:

89613174-89718511 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19211 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PTEN

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000314.4	NP_000305.3	NC_000010.9 range: 89613174..89718511

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (9187108)
GO:0005829	cytosol	Cellular Component	EXP (9593664)
GO:0005737	cytoplasm	Cellular Component	TAS (9367992)
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA
GO:0030165	PDZ domain binding	Molecular Function	IPI (10646847\|10760291)
GO:0008289	lipid binding	Molecular Function	IEA
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Molecular Function	EXP (9593664)
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Molecular Function	IDA (9593664\|9811831)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	Molecular Function	IDA (9593664)
GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	Molecular Function	IDA (9811831)
GO:0004438	phosphatidylinositol-3-phosphatase activity	Molecular Function	IDA (9811831)
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	IDA (9256433)
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IDA (9256433)
GO:0005515	protein binding	Molecular Function	IPI (15951562\|17218262\|17274640\|18064632)
GO:0031647	regulation of protein stability	Biological Process	IMP (10866658)
GO:0051895	negative regulation of focal adhesion formation	Biological Process	IMP (9616126)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0046855	inositol phosphate dephosphorylation	Biological Process	IDA (9593664)
GO:0046856	phosphoinositide dephosphorylation	Biological Process	IDA (9593664\|9811831)
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	TAS (10918569)
GO:0030336	negative regulation of cell migration	Biological Process	IMP (9616126)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (10468583)
GO:0007507	heart development	Biological Process	ISS
GO:0007417	central nervous system development	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	ISS
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	TAS (9367992)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (9256433)
GO:0051898	negative regulation of protein kinase B signaling cascade	Biological Process	IMP (10760291)