ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pten

Full Name:

phosphatase and tensin homolog

Alias:

2310035O07Rik|A130070J02Rik|AI463227|MMAC1|TEP1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 C1|19 24.5 cM

Physical Location:

32832066-32900649 on NC_000085.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5728 Symbol (Name): PTEN (phosphatase and tensin homolog (mutated in multiple advanced cancers 1))

Ortholog Status:

The human GeneID 5728 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pten
Original ID2:		U92437

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008960.2	NP_032986.1	NC_000085.5 range: 32832066..32900649

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Molecular Function	IDA (9778245)
GO:0005515	protein binding	Molecular Function	IPI (17218262)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0016477	cell migration	Biological Process	IMP (12091320)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (10339565)
GO:0043542	endothelial cell migration	Biological Process	IMP (16107612)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0048738	cardiac muscle development	Biological Process	IMP (16107612)
GO:0001525	angiogenesis	Biological Process	IMP (16107612)
GO:0016311	dephosphorylation	Biological Process	IEA
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (16027169)
GO:0008285	negative regulation of cell proliferation	Biological Process	IGI (16027168)
GO:0007507	heart development	Biological Process	IMP (15755804)
GO:0007417	central nervous system development	Biological Process	IMP (12091320)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IMP (9778245)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0051898	negative regulation of protein kinase B signaling cascade	Biological Process	IMP (10339565)