ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Park7

Full Name:

Parkinson disease (autosomal recessive, early onset) 7

Alias:

DJ-1|Dj1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 E1

Physical Location:

150271250-150283958 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 11315 Symbol (Name): PARK7 (Parkinson disease (autosomal recessive, early onset) 7)

Ortholog Status:

The human GeneID 11315 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Park7
Original ID2:		AB015652

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020569.3	NP_065594.2	NC_000070.5 range: 150271250..150283958, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISO
GO:0005737	cytoplasm	Cellular Component	ISO
GO:0005739	mitochondrion	Cellular Component	IDA (17766438)
GO:0003723	RNA binding	Molecular Function	TAS (11223268)
GO:0051920	peroxiredoxin activity	Molecular Function	IMP (17766438)
GO:0001963	synaptic transmission, dopaminergic	Biological Process	IMP (15799973)
GO:0051899	membrane depolarization	Biological Process	IMP (16624565)
GO:0051583	dopamine uptake	Biological Process	IMP (15721235)
GO:0042743	hydrogen peroxide metabolic process	Biological Process	IMP (17766438)
GO:0042542	response to hydrogen peroxide	Biological Process	IMP (15784737)
GO:0042542	response to hydrogen peroxide	Biological Process	IDA (15784737)
GO:0008344	adult locomotory behavior	Biological Process	IMP (15721235\|15799973)
GO:0008283	cell proliferation	Biological Process	TAS (11223268)
GO:0006950	response to stress	Biological Process	IMP (16624565)
GO:0060081	membrane hyperpolarization	Biological Process	IMP (16624565)