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Gene Information
Gene ID:5740235
Organism:Drosophila melanogaster (Fly)
Physical Location:23877-36734 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:RhoGAP1A
P Value:4.06E-02
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001103385.1NP_001096855.1NC_004354.3 range: 23877..36734
NM_001103386.1NP_001096856.1NC_004354.3 range: 23877..36734
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005089Rho guanyl-nucleotide exchange factor activityMolecular FunctionIEA
GO:0005096GTPase activator activityMolecular FunctionISS
GO:0035023regulation of Rho protein signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:5740235