ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RhoGAP1A

Alias:

BCR|CG17617|CG17960|CG40453|CG40494|EG:23E12.2|EG:23E12.5

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Physical Location:

23877-36734 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005096	GTPase activator activity	Molecular Function	ISS
GO:0035023	regulation of Rho protein signal transduction	Biological Process	IEA