ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

March7

Full Name:

membrane-associated ring finger (C3HC4) 7

Alias:

Axo|Axot

Organism:

Mus musculus (Mouse)

Chromosome:

2

Genetic Location:

2 C3

Physical Location:

60047992-60086441 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Axot
Original ID2:		AW212859

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Information

Original ID1:		Axot
Fold Change:		5.48
P Value:		0.005
Note:		acute functional tolerance

Dataset Information

Name:		16783646
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Alcohol preference, acute functional tolerance
Publication:		Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:		Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020575.2	NP_065600.1	NC_000068.6 range: 60047992..60086441

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND

Other Database Cross Links

NCBI Entrez Gene:

MGI:

Ensembl:

ENSMUSG00000026977

dbSNP:

AceView: