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Gene Information
Gene ID:57438
Symbol:March7
Full Name:membrane-associated ring finger (C3HC4) 7
Alias:Axo|Axot
Organism:Mus musculus (Mouse)
Chromosome:2
Genetic Location:2 C3
Physical Location:60047992-60086441 on NC_000068.6
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Axot
Original ID2:AW212859
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Information
Original ID1:Axot
Fold Change:5.48
P Value:0.005
Note:acute functional tolerance
Dataset Information
Name:16783646
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_020575.2NP_065600.1NC_000068.6 range: 60047992..60086441
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0003674molecular_functionMolecular FunctionND
GO:0005515protein bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:57438
MGI:
Ensembl:ENSMUSG00000026977
dbSNP:March7
AceView:March7