ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTN

Full Name:

pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

Alias:

HARP|HBGF8|HBNF|NEGF1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7q33-q34

Physical Location:

136562627-136679085 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.371249
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

PTN

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002825.5	NP_002816.1	NC_000007.12 range: 136562627..136679085, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	TAS (10706604)
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (11256614)
GO:0004864	protein phosphatase inhibitor activity	Molecular Function	TAS (10706604)
GO:0005125	cytokine activity	Molecular Function	NR
GO:0008201	heparin binding	Molecular Function	IEA
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0007399	nervous system development	Biological Process	TAS (2270483)
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	Biological Process	TAS (10706604)
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS (2270483)