ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTPN2

Full Name:

protein tyrosine phosphatase, non-receptor type 2

Alias:

PTPT|TC-PTP|TCELLPTP|TCPTP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

18p11.3-p11.2

Physical Location:

12775479-12874333 on NC_000018.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 117063 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D18S53

11482730

Region:		9482730-13482730
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	TAS (2546150)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12907755\|16293614)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	TAS (2546150)