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Gene Information
Gene ID:117063
Symbol:Ptpn2
Full Name:protein tyrosine phosphatase, non-receptor type 2
Organism:Rattus norvegicus (Rat)
Chromosome:18
Genetic Location:18q12.1
Physical Location:64205919-64271287 on NC_005117.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5771    Symbol (Name): PTPN2 (protein tyrosine phosphatase, non-receptor type 2)
Ortholog Status:The human GeneID 5771 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ptpn2
Fold Change:1.12
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053990.1NP_446442.1NC_005117.2 range: 64205919..64271287, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0003677DNA bindingMolecular FunctionTAS (1849097)
GO:0004726non-membrane spanning protein tyrosine phosphatase activityMolecular FunctionIDA (8534367)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessISS
GO:0008286insulin receptor signaling pathwayBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:117063
RGD:620710
Ensembl:ENSRNOG00000017453
dbSNP:Ptpn2