ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ptpn2

Full Name:

protein tyrosine phosphatase, non-receptor type 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

18q12.1

Physical Location:

64205919-64271287 on NC_005117.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5771 Symbol (Name): PTPN2 (protein tyrosine phosphatase, non-receptor type 2)

Ortholog Status:

The human GeneID 5771 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ptpn2
Fold Change:		1.12
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053990.1	NP_446442.1	NC_005117.2 range: 64205919..64271287, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0003677	DNA binding	Molecular Function	TAS (1849097)
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Molecular Function	IDA (8534367)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	ISS
GO:0008286	insulin receptor signaling pathway	Biological Process	ISS