ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RAC2

Full Name:

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

Alias:

EN-7|Gx|HSPC022

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q13.1

Physical Location:

35951255-35970250 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		RAC2
Original ID2:		H42477

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002872.3	NP_002863.1	NC_000022.9 range: 35951255..35970250, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (2674130)
GO:0005515	protein binding	Molecular Function	IPI (11090627)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	TAS (2674130)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA