ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tmod2

Full Name:

tropomodulin 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q24

Physical Location:

80392805-80419314 on NC_005107.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 29767 Symbol (Name): TMOD2 (tropomodulin 2 (neuronal))

Ortholog Status:

The human GeneID 29767 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tmod2
Fold Change:		-1.16
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031613.1	NP_113801.1	NC_005107.2 range: 80392805..80419314, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0030426	growth cone	Cellular Component	IDA (8886980)
GO:0043005	neuron projection	Cellular Component	IDA (8886980)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0003779	actin binding	Molecular Function	IDA (8886980)
GO:0005523	tropomyosin binding	Molecular Function	IEA
GO:0005523	tropomyosin binding	Molecular Function	IDA (8886980)
GO:0003779	actin binding	Molecular Function	IEA
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007611	learning and/or memory	Biological Process	ISS
GO:0007611	learning and/or memory	Biological Process	IEA
GO:0007270	nerve-nerve synaptic transmission	Biological Process	ISS
GO:0007270	nerve-nerve synaptic transmission	Biological Process	IEA
GO:0007015	actin filament organization	Biological Process	TAS (8886980)
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	Biological Process	ISS