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Gene Information
Gene ID:58814
Full Name:tropomodulin 2
Organism:Rattus norvegicus (Rat)
Genetic Location:8q24
Physical Location:80392805-80419314 on NC_005107.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 29767    Symbol (Name): TMOD2 (tropomodulin 2 (neuronal))
Ortholog Status:The human GeneID 29767 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tmod2
Fold Change:-1.16
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031613.1NP_113801.1NC_005107.2 range: 80392805..80419314, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0030426growth coneCellular ComponentIDA (8886980)
GO:0043005neuron projectionCellular ComponentIDA (8886980)
GO:0005737cytoplasmCellular ComponentIEA
GO:0003779actin bindingMolecular FunctionIDA (8886980)
GO:0005523tropomyosin bindingMolecular FunctionIEA
GO:0005523tropomyosin bindingMolecular FunctionIDA (8886980)
GO:0003779actin bindingMolecular FunctionIEA
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007611learning and/or memoryBiological ProcessISS
GO:0007611learning and/or memoryBiological ProcessIEA
GO:0007270nerve-nerve synaptic transmissionBiological ProcessISS
GO:0007270nerve-nerve synaptic transmissionBiological ProcessIEA
GO:0007015actin filament organizationBiological ProcessTAS (8886980)
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:58814