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Gene Information
Gene ID:58835
Symbol:Phgdh
Full Name:3-phosphoglycerate dehydrogenase
Alias:MGC105399
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q34
Physical Location:193147942-193177136 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 26227    Symbol (Name): PHGDH (phosphoglycerate dehydrogenase)
Ortholog Status:The human GeneID 26227 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.6872
Original ID2:Phgdh
Fold Change:1.42
P Value:0.00003
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Phgdh
Fold Change:-1.36
Tissue:Amygdala
Gene Information
Original ID1:Phgdh
Fold Change:-1.42
Tissue:Frontalcortex
Gene Information
Original ID1:Phgdh
Fold Change:-1.39
Tissue:Hippocampus
Gene Information
Original ID1:Phgdh
Fold Change:-1.33
Tissue:Caudate-putamen
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031620.1NP_113808.1NC_005101.2 range: 193147942..193177136, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0004617phosphoglycerate dehydrogenase activityMolecular FunctionIDA (9163325)
GO:0048037cofactor bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0051287NAD bindingMolecular FunctionIEA
GO:0004617phosphoglycerate dehydrogenase activityMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0009070serine family amino acid biosynthetic processBiological ProcessTAS (9163325)
GO:0006564L-serine biosynthetic processBiological ProcessIEA
GO:0008652amino acid biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:58835
RGD:61987
Ensembl:ENSRNOG00000019328
dbSNP:Phgdh