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Gene Information
Gene ID:58844
Symbol:Grb14
Full Name:growth factor receptor bound protein 14
Organism:Rattus norvegicus (Rat)
Chromosome:3
Genetic Location:3q21
Physical Location:46832379-46952669 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2888    Symbol (Name): GRB14 (growth factor receptor-bound protein 14)
Ortholog Status:The human GeneID 2888 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.30028
Original ID2:Grb14
Fold Change:1.31
P Value:0.0004
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Grb14
Fold Change:1.32
Tissue:Hippocampus
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031623.1NP_113811.1NC_005102.2 range: 46832379..46952669, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0010008endosome membraneCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0005768endosomeCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005158insulin receptor bindingMolecular FunctionIPI (9748281)
GO:0005070SH3/SH2 adaptor activityMolecular FunctionISS
GO:0007165signal transductionBiological ProcessIEA
GO:0007242intracellular signaling cascadeBiological ProcessIEP (9748281)
Other Database Cross Links
NCBI Entrez Gene:58844
RGD:61869
Ensembl:ENSRNOG00000031396
dbSNP:Grb14