Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:58852
Symbol:Nr1h3
Full Name:nuclear receptor subfamily 1, group H, member 3
Alias:LXRalpha
Organism:Rattus norvegicus (Rat)
Chromosome:3
Genetic Location:3q24
Physical Location:75542179-75550799 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10062    Symbol (Name): NR1H3 (nuclear receptor subfamily 1, group H, member 3)
Ortholog Status:The human GeneID 10062 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Nr1h3
Fold Change:1.15
P Value:0.007
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031627.2NP_113815.2NC_005102.2 range: 75542179..75550799, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (16773041)
GO:0005737cytoplasmCellular ComponentIDA (16773041)
GO:0046965retinoid X receptor bindingMolecular FunctionIPI (7935418)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0030528transcription regulator activityMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (7935418)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0003707steroid hormone receptor activityMolecular FunctionTAS (11781314)
GO:0004884ecdysteroid hormone receptor activityMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionISS
GO:0005496steroid bindingMolecular FunctionIEA
GO:0005507copper ion bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0004879ligand-dependent nuclear receptor activityMolecular FunctionISS
GO:0044255cellular lipid metabolic processBiological ProcessIEA
GO:0044255cellular lipid metabolic processBiological ProcessISS
GO:0016481negative regulation of transcriptionBiological ProcessISS
GO:0016481negative regulation of transcriptionBiological ProcessIEA
GO:0008286insulin receptor signaling pathwayBiological ProcessIEP (11781314)
GO:0006629lipid metabolic processBiological ProcessIEP (11781314)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:58852
RGD:61909
Ensembl:ENSRNOG00000013172
dbSNP:Nr1h3