ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

58852

Symbol:

Nr1h3

Full Name:

nuclear receptor subfamily 1, group H, member 3

Alias:

LXRalpha

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q24

Physical Location:

75542179-75550799 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10062 Symbol (Name): NR1H3 (nuclear receptor subfamily 1, group H, member 3)

Ortholog Status:

The human GeneID 10062 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nr1h3
Fold Change:		1.15
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031627.2	NP_113815.2	NC_005102.2 range: 75542179..75550799, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (16773041)
GO:0005737	cytoplasm	Cellular Component	IDA (16773041)
GO:0046965	retinoid X receptor binding	Molecular Function	IPI (7935418)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (7935418)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0003707	steroid hormone receptor activity	Molecular Function	TAS (11781314)
GO:0004884	ecdysteroid hormone receptor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0005496	steroid binding	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	ISS
GO:0044255	cellular lipid metabolic process	Biological Process	IEA
GO:0044255	cellular lipid metabolic process	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	IEA
GO:0008286	insulin receptor signaling pathway	Biological Process	IEP (11781314)
GO:0006629	lipid metabolic process	Biological Process	IEP (11781314)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA