Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:58942
Symbol:Cacnb4
Full Name:calcium channel, voltage-dependent, beta 4 subunit
Organism:Rattus norvegicus (Rat)
Chromosome:3
Genetic Location:3q12
Physical Location:33934331-34193690 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 785    Symbol (Name): CACNB4 (calcium channel, voltage-dependent, beta 4 subunit)
Ortholog Status:The human GeneID 785 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cacnb4
Fold Change:-1.2
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Cacnb4
Fold Change:-1.31
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Cacnb4
Fold Change:-1.2
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_215742.4XP_215742.2NC_005102.2 range: 33934331..34193690, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005891voltage-gated calcium channel complexCellular ComponentISS
GO:0005891voltage-gated calcium channel complexCellular ComponentIMP (12821675)
GO:0005245voltage-gated calcium channel activityMolecular FunctionIMP (12821675)
GO:0005515protein bindingMolecular FunctionISS
GO:0005245voltage-gated calcium channel activityMolecular FunctionISS
GO:0005245voltage-gated calcium channel activityMolecular FunctionISS
GO:0046058cAMP metabolic processBiological ProcessISS
GO:0048536spleen developmentBiological ProcessISS
GO:0048538thymus developmentBiological ProcessISS
GO:0048541Peyer's patch developmentBiological ProcessISS
GO:0048747muscle fiber developmentBiological ProcessISS
GO:0050852T cell receptor signaling pathwayBiological ProcessISS
GO:0050877neurological system processBiological ProcessISS
GO:0051925regulation of calcium ion transport via voltage-gated calcium channelBiological ProcessISS
GO:0042391regulation of membrane potentialBiological ProcessISS
GO:0035249synaptic transmission, glutamatergicBiological ProcessISS
GO:0030217T cell differentiationBiological ProcessISS
GO:0006816calcium ion transportBiological ProcessIMP (12821675)
GO:0006816calcium ion transportBiological ProcessISS
GO:0006874cellular calcium ion homeostasisBiological ProcessISS
GO:0007214gamma-aminobutyric acid signaling pathwayBiological ProcessISS
GO:0007528neuromuscular junction developmentBiological ProcessISS
GO:0007628adult walking behaviorBiological ProcessISS
GO:0014051gamma-aminobutyric acid secretionBiological ProcessISS
GO:0019227action potential propagationBiological ProcessISS
GO:0051932synaptic transmission, GABAergicBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:58942
RGD:68385
Ensembl:ENSRNOG00000007666
dbSNP:Cacnb4