ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

5901

Symbol:

RAN

Full Name:

RAN, member RAS oncogene family

Alias:

ARA24|Gsp1|TC4

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12q24.3

Physical Location:

129922520-129927315 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 44072 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF052578
Fold Change:		1.4, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Gene Information

Original ID1:		AF054183
Fold Change:		1.4, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

RAN

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006325.2	NP_006316.1	NC_000012.10 range: 129922520..129927315

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000785	chromatin	Cellular Component	IDA (1961752)
GO:0042470	melanosome	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (7878053)
GO:0005737	cytoplasm	Cellular Component	IDA (1961752)
GO:0005654	nucleoplasm	Cellular Component	EXP (9405152\|9837918)
GO:0005643	nuclear pore	Cellular Component	NAS (8421051)
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0050681	androgen receptor binding	Molecular Function	NAS (15572661)
GO:0005525	GTP binding	Molecular Function	IDA (1961752)
GO:0005515	protein binding	Molecular Function	IPI (1961752)
GO:0003924	GTPase activity	Molecular Function	TAS (10400640)
GO:0003924	GTPase activity	Molecular Function	EXP (7878053)
GO:0003713	transcription coactivator activity	Molecular Function	NAS (15572661)
GO:0003682	chromatin binding	Molecular Function	TAS (1961752)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS (15572661)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	NAS (15572661)
GO:0007165	signal transduction	Biological Process	TAS (7603572)
GO:0007067	mitosis	Biological Process	TAS (8421051)
GO:0007052	mitotic spindle organization and biogenesis	Biological Process	TAS (10408446)
GO:0006913	nucleocytoplasmic transport	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006611	protein export from nucleus	Biological Process	NAS
GO:0006405	RNA export from nucleus	Biological Process	NAS
GO:0006259	DNA metabolic process	Biological Process	TAS (8421051)