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Gene Information
Gene ID:5901
Full Name:RAN, member RAS oncogene family
Organism:Homo sapiens (Human)
Genetic Location:12q24.3
Physical Location:129922520-129927315 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has Fly: 44072 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF052578
Fold Change:1.4, 1.4
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Gene Information
Original ID1:AF054183
Fold Change:1.4, 1.4
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:RAN
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006325.2NP_006316.1NC_000012.10 range: 129922520..129927315
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000785chromatinCellular ComponentIDA (1961752)
GO:0042470melanosomeCellular ComponentIEA
GO:0005829cytosolCellular ComponentEXP (7878053)
GO:0005737cytoplasmCellular ComponentIDA (1961752)
GO:0005654nucleoplasmCellular ComponentEXP (9405152|9837918)
GO:0005643nuclear poreCellular ComponentNAS (8421051)
GO:0005634nucleusCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0050681androgen receptor bindingMolecular FunctionNAS (15572661)
GO:0005525GTP bindingMolecular FunctionIDA (1961752)
GO:0005515protein bindingMolecular FunctionIPI (1961752)
GO:0003924GTPase activityMolecular FunctionTAS (10400640)
GO:0003924GTPase activityMolecular FunctionEXP (7878053)
GO:0003713transcription coactivator activityMolecular FunctionNAS (15572661)
GO:0003682chromatin bindingMolecular FunctionTAS (1961752)
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0030521androgen receptor signaling pathwayBiological ProcessNAS (15572661)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessNAS (15572661)
GO:0007165signal transductionBiological ProcessTAS (7603572)
GO:0007067mitosisBiological ProcessTAS (8421051)
GO:0007052mitotic spindle organization and biogenesisBiological ProcessTAS (10408446)
GO:0006913nucleocytoplasmic transportBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0006611protein export from nucleusBiological ProcessNAS
GO:0006405RNA export from nucleusBiological ProcessNAS
GO:0006259DNA metabolic processBiological ProcessTAS (8421051)
Other Database Cross Links
NCBI Entrez Gene:5901
HuGE Navigator:5901