ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ran

Alias:

AAF30287|CG1404|dran|l(1)G0075|ran10A

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

10A8-10A8

Physical Location:

11038894-11042621 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5901 Symbol (Name): RAN (RAN, member RAS oncogene family)

Ortholog Status:

The human GeneID 5901 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		ran
P Value:		4.70E-02
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (12653959)
GO:0005811	lipid particle	Cellular Component	IDA (16979555)
GO:0003924	GTPase activity	Molecular Function	ISS (14579253)
GO:0005515	protein binding	Molecular Function	IPI (12653959)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IMP (14527345)
GO:0007015	actin filament organization	Biological Process	IMP (14527345)
GO:0006913	nucleocytoplasmic transport	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0008360	regulation of cell shape	Biological Process	IMP (14527345)