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Gene Information
Gene ID:44072
Organism:Drosophila melanogaster (Fly)
Genetic Location:10A8-10A8
Physical Location:11038894-11042621 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5901    Symbol (Name): RAN (RAN, member RAS oncogene family)
Ortholog Status:The human GeneID 5901 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ran
P Value:4.70E-02
Note:Slow down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_143712.2NP_651969.1NC_004354.3 range: 11038894..11042621, complement
NM_167272.1NP_727499.1NC_004354.3 range: 11038894..11042621, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (12653959)
GO:0005811lipid particleCellular ComponentIDA (16979555)
GO:0003924GTPase activityMolecular FunctionISS (14579253)
GO:0005515protein bindingMolecular FunctionIPI (12653959)
GO:0005525GTP bindingMolecular FunctionIEA
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessIMP (14527345)
GO:0007015actin filament organizationBiological ProcessIMP (14527345)
GO:0006913nucleocytoplasmic transportBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0008360regulation of cell shapeBiological ProcessIMP (14527345)
Other Database Cross Links
NCBI Entrez Gene:44072