ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RFC1

Full Name:

replication factor C (activator 1) 1, 145kDa

Alias:

A1|MGC51786|MHCBFB|PO-GA|RECC1|RFC|RFC140

Organism:

Homo sapiens (Human)

Chromosome:

4

Genetic Location:

4p14-p13

Physical Location:

38965470-39044389 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.507475
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

RFC1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002913.3	NP_002904.3	NC_000004.10 range: 38965470..39044389, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (9822671)
GO:0005663	DNA replication factor C complex	Cellular Component	IDA (9488738)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008047	enzyme activator activity	Molecular Function	TAS (8954124)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	TAS (8248204)
GO:0005515	protein binding	Molecular Function	IPI (16438930)
GO:0003689	DNA clamp loader activity	Molecular Function	IEA
GO:0006297	nucleotide-excision repair, DNA gap filling	Biological Process	EXP (9111189)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007004	telomere maintenance via telomerase	Biological Process	TAS (8954124)
GO:0006261	DNA-dependent DNA replication	Biological Process	TAS (8248204)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000035928

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: