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Gene Information
Gene ID:5981
Symbol:RFC1
Full Name:replication factor C (activator 1) 1, 145kDa
Alias:A1|MGC51786|MHCBFB|PO-GA|RECC1|RFC|RFC140
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4p14-p13
Physical Location:38965470-39044389 on NC_000004.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.507475
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:RFC1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002913.3NP_002904.3NC_000004.10 range: 38965470..39044389, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005654nucleoplasmCellular ComponentEXP (9822671)
GO:0005663DNA replication factor C complexCellular ComponentIDA (9488738)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0017111nucleoside-triphosphatase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008047enzyme activator activityMolecular FunctionTAS (8954124)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionTAS (8248204)
GO:0005515protein bindingMolecular FunctionIPI (16438930)
GO:0003689DNA clamp loader activityMolecular FunctionIEA
GO:0006297nucleotide-excision repair, DNA gap fillingBiological ProcessEXP (9111189)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0007004telomere maintenance via telomeraseBiological ProcessTAS (8954124)
GO:0006261DNA-dependent DNA replicationBiological ProcessTAS (8248204)
Other Database Cross Links
NCBI Entrez Gene:5981
HGNC:9969
Ensembl:ENSG00000035928
MIM:102579
HPRD:00024
HuGE Navigator:5981
dbSNP:RFC1
GeneCard:RFC1
AceView:RFC1