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Gene Information
Gene ID:5991
Symbol:RFX3
Full Name:regulatory factor X, 3 (influences HLA class II expression)
Alias:MGC87155|bA32F11.1
Organism:Homo sapiens (Human)
Chromosome:9
Genetic Location:9p24.2
Physical Location:3214644-3515982 on NC_000009.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.136829
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002919.2NP_002910.1NC_000009.10 range: 3214644..3515982, complement
NM_134428.1NP_602304.1NC_000009.10 range: 3214644..3515982, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIC (12411430)
GO:0005634nucleusCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingMolecular FunctionTAS (8289803)
GO:0016564transcription repressor activityMolecular FunctionIDA (12411430)
GO:0030528transcription regulator activityMolecular FunctionIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0016481negative regulation of transcriptionBiological ProcessIDA (12411430)
GO:0045449regulation of transcriptionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:5991
HGNC:9984
Ensembl:ENSG00000080298
MIM:601337
HPRD:03215
HuGE Navigator:5991
dbSNP:RFX3
GeneCard:RFX3
AceView:RFX3