ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RFX3

Full Name:

regulatory factor X, 3 (influences HLA class II expression)

Alias:

MGC87155|bA32F11.1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9p24.2

Physical Location:

3214644-3515982 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.136829
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IC (12411430)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	Molecular Function	TAS (8289803)
GO:0016564	transcription repressor activity	Molecular Function	IDA (12411430)
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0016481	negative regulation of transcription	Biological Process	IDA (12411430)
GO:0045449	regulation of transcription	Biological Process	IEA