ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Arhgef1

Full Name:

Rho guanine nucleotide exchange factor (GEF) 1

Alias:

Lsc|MGC108950

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q21

Physical Location:

80209458-80226352 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9138 Symbol (Name): ARHGEF1 (Rho guanine nucleotide exchange factor (GEF) 1)

Ortholog Status:

The human GeneID 9138 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Arhgef1
Fold Change:		1.19
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021694.3	NP_067726.3	NC_005100.2 range: 80209458..80226352

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005096	GTPase activator activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI
GO:0005515	protein binding	Molecular Function	ISS
GO:0035023	regulation of Rho protein signal transduction	Biological Process	IEA