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Gene Information
Gene ID:60430
Symbol:Mcl1
Full Name:myeloid cell leukemia sequence 1
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q34
Gene Type:protein-coding
Human Ortholog:GeneID: 4170    Symbol (Name): MCL1 (myeloid cell leukemia sequence 1 (BCL2-related))
Ortholog Status:The human GeneID 4170 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mcl1
Fold Change:1.12
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Mcl1
Fold Change:1.12
P Value:0.01
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0046982protein heterodimerization activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0046983protein dimerization activityMolecular FunctionIPI
GO:0030154cell differentiationBiological ProcessIEA
GO:0042981regulation of apoptosisBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:60430
RGD:620525
Ensembl:
dbSNP:Mcl1