ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Syt6

Full Name:

synaptotagmin VI

Alias:

MGC116356

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

198807339-198862226 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 148281 Symbol (Name): SYT6 (synaptotagmin VI)

Ortholog Status:

The human GeneID 148281 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Syt6
Fold Change:		-1.22
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Syt6
Fold Change:		-1.21
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022191.1	NP_071527.1	NC_005101.2 range: 198807339..198862226

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0008021	synaptic vesicle	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0019905	syntaxin binding	Molecular Function	IDA (7791877)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0048306	calcium-dependent protein binding	Molecular Function	ISS
GO:0007340	acrosome reaction	Biological Process	ISS
GO:0006897	endocytosis	Biological Process	IPI (7791877)
GO:0006810	transport	Biological Process	IEA