ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pik3r3

Full Name:

phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q36

Physical Location:

136497493-136566472 on NC_005104.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8503 Symbol (Name): PIK3R3 (phosphoinositide-3-kinase, regulatory subunit 3 (gamma))

Ortholog Status:

The human GeneID 8503 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pik3r3
Fold Change:		-1.16
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022213.1	NP_071549.1	NC_005104.2 range: 136497493..136566472

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005942	phosphoinositide 3-kinase complex	Cellular Component	IEA
GO:0005942	phosphoinositide 3-kinase complex	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0035014	phosphoinositide 3-kinase regulator activity	Molecular Function	IEA
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Molecular Function	IDA (8621382)
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Molecular Function	ISS
GO:0008286	insulin receptor signaling pathway	Biological Process	ISS