ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gpd1

Full Name:

glycerol-3-phosphate dehydrogenase 1 (soluble)

Alias:

GPDH|Gpd3|MGC93453

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q36

Physical Location:

138458874-138466265 on NC_005106.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2819 Symbol (Name): GPD1 (glycerol-3-phosphate dehydrogenase 1 (soluble))

Ortholog Status:

The human GeneID 2819 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gpd1
Fold Change:		1.2
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Gpd1
Fold Change:		1.44
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Gpd1
Fold Change:		1.23
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Gpd1
Fold Change:		1.22
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022215.2	NP_071551.2	NC_005106.2 range: 138458874..138466265

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009331	glycerol-3-phosphate dehydrogenase complex	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (1834654)
GO:0005625	soluble fraction	Cellular Component	IDA (1834654\|9550546)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004367	glycerol-3-phosphate dehydrogenase (NAD+) activity	Molecular Function	IDA (9550546)
GO:0051287	NAD binding	Molecular Function	IDA (9550546)
GO:0051287	NAD binding	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0004367	glycerol-3-phosphate dehydrogenase (NAD+) activity	Molecular Function	IEA
GO:0004368	glycerol-3-phosphate dehydrogenase activity	Molecular Function	IDA (1834654)
GO:0004367	glycerol-3-phosphate dehydrogenase (NAD+) activity	Molecular Function	TAS (12533437)
GO:0046486	glycerolipid metabolic process	Biological Process	IDA (2997397)
GO:0046168	glycerol-3-phosphate catabolic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006116	NADH oxidation	Biological Process	IDA (9550546)
GO:0006094	gluconeogenesis	Biological Process	ISS
GO:0006094	gluconeogenesis	Biological Process	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IDA (1834654)
GO:0006072	glycerol-3-phosphate metabolic process	Biological Process	ISS