| Gene Information |
| Gene ID: | | 6164 |
| Symbol: | | RPL34 |
| Full Name: | | ribosomal protein L34 |
| Alias: | | MGC111005 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 4 |
| Genetic Location: | | 4q25 |
| Physical Location: | | 109761170-109771088 on NC_000004.10 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Hs.438227 | | Note: | | "Class II, up-regulated gene" |
| | Dataset Information | | Name: | | 16292326 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed | | Summary: | | In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D4S423 | 2.61 | 0.0003 | 92691777 | | D4S427 | 3.53 | 0.00003 | 121646580 | | Region: | | 92691777-121646580 | | Phenotype: | | ADSX (number of DSM-IV AD symptoms) | | Name: | | 16534506 | | Method: | | Linkage | | Publication: | | Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed | | Summary: | | We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005622 | intracellular | Cellular Component | IEA | |
| GO:0005829 | cytosol | Cellular Component | EXP (14567916) | |
| GO:0005840 | ribosome | Cellular Component | IEA | |
| GO:0022625 | cytosolic large ribosomal subunit | Cellular Component | TAS (7490091) | |
| GO:0003723 | RNA binding | Molecular Function | TAS (7490091) | |
| GO:0003735 | structural constituent of ribosome | Molecular Function | TAS (7490091) | |
| GO:0005515 | protein binding | Molecular Function | IPI (17353931) | |
| GO:0006414 | translational elongation | Biological Process | EXP (15189156) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 6164 |
| HGNC: | | 10340 |
| Ensembl: | | ENSG00000109475 |
| MIM: | | |
| HPRD: | | 17996 |
| HuGE Navigator: | | 6164 |
| dbSNP: | | RPL34 |
| GeneCard: | | RPL34 |
| AceView: | | RPL34 |
