ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RPS6KA1

Full Name:

ribosomal protein S6 kinase, 90kDa, polypeptide 1

Alias:

HU-1|MAPKAPK1A|RSK|RSK1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

Physical Location:

26728835-26774106 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20111 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.149957
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	EXP (9770464\|16626623)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16282323)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (8141249)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	EXP (9770464)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (8141249)
GO:0007243	protein kinase cascade	Biological Process	IEA