ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RTKN

Full Name:

rhotekin

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2p13.1

Physical Location:

74506495-74522567 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.192854
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001015055.1	NP_001015055.1	NC_000002.10 range: 74506495..74522567, complement
NM_001015056.1	NP_001015056.1	NC_000002.10 range: 74506495..74522567, complement
NM_033046.2	NP_149035.1	NC_000002.10 range: 74506495..74522567, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0017049	GTP-Rho binding	Molecular Function	IDA (10940294)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10940294\|16007136)
GO:0005095	GTPase inhibitor activity	Molecular Function	IDA (10940294)
GO:0006915	apoptosis	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IDA (10940294)
GO:0007266	Rho protein signal transduction	Biological Process	IDA (15480428)
GO:0045767	regulation of anti-apoptosis	Biological Process	IDA (15480428)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000114993

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: