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Gene Information
Gene ID:6347
Full Name:chemokine (C-C motif) ligand 2
Organism:Homo sapiens (Human)
Genetic Location:17q11.2-q12
Physical Location:29606408-29608334 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:MCP1
Original ID2:M26683
Dataset Information
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:CCL2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S798  28313925
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002982.3NP_002973.1NC_000017.9 range: 29606408..29608334
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentTAS (10942204)
GO:0016020membraneCellular ComponentIEA
GO:0004672protein kinase activityMolecular FunctionTAS (9973507)
GO:0004871signal transducer activityMolecular FunctionTAS (10198043|10770925)
GO:0008009chemokine activityMolecular FunctionTAS (10623817)
GO:0007259JAK-STAT cascadeBiological ProcessTAS (9670957)
GO:0007267cell-cell signalingBiological ProcessNR
GO:0009887organ morphogenesisBiological ProcessTAS (9364936)
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerBiological ProcessTAS (10770925)
GO:0007155cell adhesionBiological ProcessTAS (10198043)
GO:0006959humoral immune responseBiological ProcessTAS (9548499)
GO:0006954inflammatory responseBiological ProcessIEA
GO:0006935chemotaxisBiological ProcessTAS (10623817)
GO:0006916anti-apoptosisBiological ProcessIDA (12753088)
GO:0006874cellular calcium ion homeostasisBiological ProcessTAS (9670957)
GO:0006468protein amino acid phosphorylationBiological ProcessTAS (9670957)
GO:0019079viral genome replicationBiological ProcessTAS (10985244)
Other Database Cross Links
NCBI Entrez Gene:6347
HuGE Navigator:6347