ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CCL2

Full Name:

chemokine (C-C motif) ligand 2

Alias:

GDCF-2|HC11|HSMCR30|MCAF|MCP-1|MCP1|MGC9434|SCYA2|SMC-CF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q11.2-q12

Physical Location:

29606408-29608334 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		MCP1
Original ID2:		M26683

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Information

Original ID1:

CCL2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S798

28313925

Region:		26313925-30313925
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002982.3	NP_002973.1	NC_000017.9 range: 29606408..29608334

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	TAS (10942204)
GO:0016020	membrane	Cellular Component	IEA
GO:0004672	protein kinase activity	Molecular Function	TAS (9973507)
GO:0004871	signal transducer activity	Molecular Function	TAS (10198043\|10770925)
GO:0008009	chemokine activity	Molecular Function	TAS (10623817)
GO:0007259	JAK-STAT cascade	Biological Process	TAS (9670957)
GO:0007267	cell-cell signaling	Biological Process	NR
GO:0009887	organ morphogenesis	Biological Process	TAS (9364936)
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	Biological Process	TAS (10770925)
GO:0007155	cell adhesion	Biological Process	TAS (10198043)
GO:0006959	humoral immune response	Biological Process	TAS (9548499)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0006935	chemotaxis	Biological Process	TAS (10623817)
GO:0006916	anti-apoptosis	Biological Process	IDA (12753088)
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS (9670957)
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9670957)
GO:0019079	viral genome replication	Biological Process	TAS (10985244)