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Gene Information
Gene ID:63864
Full Name:hydroxysteroid (17-beta) dehydrogenase 10
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq21
Physical Location:41489342-41491787 on NC_005120.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3028    Symbol (Name): HSD17B10 (hydroxysteroid (17-beta) dehydrogenase 10)
Ortholog Status:The human GeneID 3028 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hadh2
Fold Change:1.13
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031682.1NP_113870.1NC_005120.2 range: 41489342..41491787
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005743mitochondrial inner membraneCellular ComponentISS
GO:0005783endoplasmic reticulumCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIDA (11165016)
GO:0005739mitochondrionCellular ComponentISS
GO:0005743mitochondrial inner membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:00038573-hydroxyacyl-CoA dehydrogenase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005488bindingMolecular FunctionIEA
GO:00470153-hydroxy-2-methylbutyryl-CoA dehydrogenase activityMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:63864