ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hsd17b10

Full Name:

hydroxysteroid (17-beta) dehydrogenase 10

Alias:

Hadh2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq21

Physical Location:

41489342-41491787 on NC_005120.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3028 Symbol (Name): HSD17B10 (hydroxysteroid (17-beta) dehydrogenase 10)

Ortholog Status:

The human GeneID 3028 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hadh2
Fold Change:		1.13
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031682.1	NP_113870.1	NC_005120.2 range: 41489342..41491787

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005743	mitochondrial inner membrane	Cellular Component	ISS
GO:0005783	endoplasmic reticulum	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	IDA (11165016)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005488	binding	Molecular Function	IEA
GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA