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Gene Information
Gene ID:63879
Full Name:baculoviral IAP repeat-containing 4
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq11
Physical Location:3011519-3047797 on NC_005120.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 331    Symbol (Name): XIAP (X-linked inhibitor of apoptosis)
Ortholog Status:The human GeneID 331 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Birc4
Fold Change:-1.3
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022231.2NP_071567.1NC_005120.2 range: 3011519..3047797, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0043027caspase inhibitor activityMolecular FunctionISS
GO:0016874ligase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0006916anti-apoptosisBiological ProcessIEA
GO:0006916anti-apoptosisBiological ProcessTAS (11860601)
GO:0006915apoptosisBiological ProcessIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0043154negative regulation of caspase activityBiological ProcessISS
GO:0006916anti-apoptosisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:63879