ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Birc4

Full Name:

baculoviral IAP repeat-containing 4

Alias:

Api3|Xiap|riap3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq11

Physical Location:

3011519-3047797 on NC_005120.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 331 Symbol (Name): XIAP (X-linked inhibitor of apoptosis)

Ortholog Status:

The human GeneID 331 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Birc4
Fold Change:		-1.3
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022231.2	NP_071567.1	NC_005120.2 range: 3011519..3047797, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0043027	caspase inhibitor activity	Molecular Function	ISS
GO:0016874	ligase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0006916	anti-apoptosis	Biological Process	IEA
GO:0006916	anti-apoptosis	Biological Process	TAS (11860601)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0043154	negative regulation of caspase activity	Biological Process	ISS
GO:0006916	anti-apoptosis	Biological Process	ISS