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Gene Information
Gene ID:64014
Symbol:Dusp12
Full Name:dual specificity phosphatase 12
Alias:GKAP
Organism:Rattus norvegicus (Rat)
Chromosome:13
Genetic Location:13q24
Physical Location:86737092-86746185 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 11266    Symbol (Name): DUSP12 (dual specificity phosphatase 12)
Ortholog Status:The human GeneID 11266 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dusp12
Fold Change:-1.15
P Value:0.008
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022248.1NP_071584.1NC_005112.2 range: 86737092..86746185, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIDA (10913113)
GO:0004725protein tyrosine phosphatase activityMolecular FunctionIEA
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionIEA
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionISS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:64014
RGD:68375
Ensembl:ENSRNOG00000000710
dbSNP:Dusp12