ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc33a1

Full Name:

solute carrier family 33 (acetyl-CoA transporter), member 1

Alias:

Acatn

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q31

Physical Location:

153768884-153791101 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9197 Symbol (Name): SLC33A1 (solute carrier family 33 (acetyl-CoA transporter), member 1)

Ortholog Status:

The human GeneID 9197 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slc33a1
Fold Change:		1.23
P Value:		0.008
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Slc33a1
Fold Change:		1.14
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022252.2	NP_071588.2	NC_005101.2 range: 153768884..153791101, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0008521	acetyl-CoA transporter activity	Molecular Function	NAS (10965123)
GO:0006810	transport	Biological Process	IEA
GO:0007417	central nervous system development	Biological Process	NAS (10965123)