ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

64030

Symbol:

Kit

Full Name:

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14p11

Physical Location:

34906042-34984818 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3815 Symbol (Name): KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)

Ortholog Status:

The human GeneID 3815 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.54004
Original ID2:		Kit
Fold Change:		1.27
P Value:		0.00627
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022264.1	NP_071600.1	NC_005113.2 range: 34906042..34984818, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005020	stem cell factor receptor activity	Molecular Function	ISS
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IDA (1912577)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	NAS (1912577)
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	ISS
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	ISS
GO:0030097	hemopoiesis	Biological Process	ISS
GO:0043406	positive regulation of MAP kinase activity	Biological Process	ISS
GO:0048066	pigmentation during development	Biological Process	ISS
GO:0043473	pigmentation	Biological Process	ISS
GO:0009314	response to radiation	Biological Process	ISS
GO:0008284	positive regulation of cell proliferation	Biological Process	ISS
GO:0007283	spermatogenesis	Biological Process	IMP (12932303)
GO:0007243	protein kinase cascade	Biological Process	ISS
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0050673	epithelial cell proliferation	Biological Process	IMP (12821048)