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Gene Information
Gene ID:64037
Full Name:solute carrier family 22 (organic cation transporter), member 4
Organism:Rattus norvegicus (Rat)
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Slc22a4
Fold Change:-1.13
P Value:0.003
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0015651quaternary ammonium group transmembrane transporter activityMolecular FunctionIMP (10825452)
GO:0015651quaternary ammonium group transmembrane transporter activityMolecular FunctionIDA (17616214)
GO:0015293symporter activityMolecular FunctionIEA
GO:0015101organic cation transmembrane transporter activityMolecular FunctionIDA (10825452)
GO:0015075ion transmembrane transporter activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0006814sodium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0015697quaternary ammonium group transportBiological ProcessIDA (17616214)
GO:0015697quaternary ammonium group transportBiological ProcessIMP (10825452)
Other Database Cross Links
NCBI Entrez Gene:64037