ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc22a4

Full Name:

solute carrier family 22 (organic cation transporter), member 4

Alias:

Octn1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slc22a4
Fold Change:		-1.13
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0015651	quaternary ammonium group transmembrane transporter activity	Molecular Function	IMP (10825452)
GO:0015651	quaternary ammonium group transmembrane transporter activity	Molecular Function	IDA (17616214)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0015101	organic cation transmembrane transporter activity	Molecular Function	IDA (10825452)
GO:0015075	ion transmembrane transporter activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0015697	quaternary ammonium group transport	Biological Process	IDA (17616214)
GO:0015697	quaternary ammonium group transport	Biological Process	IMP (10825452)