ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dlg2

Full Name:

discs, large homolog 2 (Drosophila)

Alias:

Dlgh2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q32

Physical Location:

147878882-149274632 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1740 Symbol (Name): DLG2 (discs, large homolog 2, chapsyn-110 (Drosophila))

Ortholog Status:

The human GeneID 1740 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dlgh2
Fold Change:		-1.17
P Value:		0.01
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Dlgh2
Fold Change:		1.24
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022282.1	NP_071618.1	NC_005100.2 range: 147878882..149274632

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	IMP (8755482)
GO:0045211	postsynaptic membrane	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0030165	PDZ domain binding	Molecular Function	IPI (15024025)
GO:0008022	protein C-terminus binding	Molecular Function	TAS (8755482)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (8755482)
GO:0019233	sensory perception of pain	Biological Process	ISS
GO:0043113	receptor clustering	Biological Process	IMP (8755482)
GO:0045161	neuronal ion channel clustering	Biological Process	IMP (8755482)
GO:0007268	synaptic transmission	Biological Process	ISS