ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddah1

Full Name:

dimethylarginine dimethylaminohydrolase 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q44

Physical Location:

243932220-244069829 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23576 Symbol (Name): DDAH1 (dimethylarginine dimethylaminohydrolase 1)

Ortholog Status:

The human GeneID 23576 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.7398
Original ID2:		Ddah1
Fold Change:		1.28
P Value:		0.00357
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022297.2	NP_071633.1	NC_005101.2 range: 243932220..244069829

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016597	amino acid binding	Molecular Function	IDA (17322279)
GO:0016403	dimethylargininase activity	Molecular Function	TAS (9003431)
GO:0016403	dimethylargininase activity	Molecular Function	IEA
GO:0016403	dimethylargininase activity	Molecular Function	IDA (12237779\|17322279)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006525	arginine metabolic process	Biological Process	IDA (17322279)
GO:0045429	positive regulation of nitric oxide biosynthetic process	Biological Process	IMP (12237779)
GO:0045766	positive regulation of angiogenesis	Biological Process	IMP (12237779)