ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tuba1a

Full Name:

tubulin, alpha 1A

Alias:

Tuba1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q36

Physical Location:

137729404-137733070 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7846 Symbol (Name): TUBA1A (tubulin, alpha 1a)

Ortholog Status:

The human GeneID 7846 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.54749
Original ID2:		Tuba1
Fold Change:		1.26
P Value:		0
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022298.1	NP_071634.1	NC_005106.2 range: 137729404..137733070, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005874	microtubule	Cellular Component	TAS (12379108)
GO:0043234	protein complex	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	TAS (12379108)
GO:0019904	protein domain specific binding	Molecular Function	IDA (12750376)
GO:0007018	microtubule-based movement	Biological Process	IEA
GO:0007017	microtubule-based process	Biological Process	TAS (12379108)
GO:0051258	protein polymerization	Biological Process	IEA