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Gene Information
Gene ID:64161
Symbol:Pi4ka
Full Name:phosphatidylinositol 4-kinase, catalytic, alpha
Alias:Pik4ca
Organism:Rattus norvegicus (Rat)
Chromosome:11
Genetic Location:11q23
Physical Location:85610280-85726602 on NC_005110.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5297    Symbol (Name): PI4KA (phosphatidylinositol 4-kinase, catalytic, alpha)
Ortholog Status:The human GeneID 5297 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pik4ca
Fold Change:1.21
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Pik4ca
Fold Change:1.13
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022301.1NP_071637.1NC_005110.2 range: 85610280..85726602
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030660Golgi-associated vesicle membraneCellular ComponentIDA (8662589)
GO:00044301-phosphatidylinositol 4-kinase activityMolecular FunctionIDA (8662589)
GO:0005488bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0016740transferase activityMolecular FunctionIEA
GO:0046854phosphoinositide phosphorylationBiological ProcessIEA
GO:0048015phosphoinositide-mediated signalingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:64161
RGD:621213
Ensembl:ENSRNOG00000001866
dbSNP:Pi4ka