ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Qdpr

Full Name:

quinoid dihydropteridine reductase

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q21

Physical Location:

70741997-70755599 on NC_005113.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5860 Symbol (Name): QDPR (quinoid dihydropteridine reductase)

Ortholog Status:

The human GeneID 5860 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.241
Original ID2:		Qdpr
Fold Change:		1.3
P Value:		0.00001
Note:		higher levels in hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.241
Original ID2:		Qdpr
Fold Change:		1.43
P Value:		0.00002
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022390.1	NP_071785.1	NC_005113.2 range: 70741997..70755599

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0004155	6,7-dihydropteridine reductase activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0006729	tetrahydrobiopterin biosynthetic process	Biological Process	IEA
GO:0006729	tetrahydrobiopterin biosynthetic process	Biological Process	TAS (3680258)
GO:0008152	metabolic process	Biological Process	IEA