ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aplp2

Full Name:

amyloid beta (A4) precursor-like protein 2

Alias:

Apph|WALPLP2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q13

Gene Type:

protein-coding

Human Ortholog:

GeneID: 334 Symbol (Name): APLP2 (amyloid beta (A4) precursor-like protein 2)

Ortholog Status:

The human GeneID 334 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Aplp2
Fold Change:		-1.3
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0001967	suckling behavior	Biological Process	ISS
GO:0030901	midbrain development	Biological Process	ISS
GO:0030900	forebrain development	Biological Process	ISS
GO:0030198	extracellular matrix organization and biogenesis	Biological Process	ISS
GO:0009790	embryonic development	Biological Process	ISS
GO:0007626	locomotory behavior	Biological Process	ISS
GO:0007617	mating behavior	Biological Process	ISS
GO:0007176	regulation of epidermal growth factor receptor activity	Biological Process	ISS
GO:0006878	cellular copper ion homeostasis	Biological Process	ISS
GO:0050885	neuromuscular process controlling balance	Biological Process	ISS