Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:64312
Full Name:amyloid beta (A4) precursor-like protein 2
Organism:Rattus norvegicus (Rat)
Genetic Location:8q13
Gene Type:protein-coding
Human Ortholog:GeneID: 334    Symbol (Name): APLP2 (amyloid beta (A4) precursor-like protein 2)
Ortholog Status:The human GeneID 334 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Aplp2
Fold Change:-1.3
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005515protein bindingMolecular FunctionISS
GO:0001967suckling behaviorBiological ProcessISS
GO:0030901midbrain developmentBiological ProcessISS
GO:0030900forebrain developmentBiological ProcessISS
GO:0030198extracellular matrix organization and biogenesisBiological ProcessISS
GO:0009790embryonic developmentBiological ProcessISS
GO:0007626locomotory behaviorBiological ProcessISS
GO:0007617mating behaviorBiological ProcessISS
GO:0007176regulation of epidermal growth factor receptor activityBiological ProcessISS
GO:0006878cellular copper ion homeostasisBiological ProcessISS
GO:0050885neuromuscular process controlling balanceBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:64312