ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SGCA

Full Name:

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

Alias:

50-DAG|A2|ADL|DAG2|DMDA2|LGMD2D|SCARMD1|adhalin

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q21

Physical Location:

45598389-45608287 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.463412
Note:		"Class I, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000023.1	NP_000014.1	NC_000017.9 range: 45598389..45608287

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0016012	sarcoglycan complex	Cellular Component	IEA
GO:0016010	dystrophin-associated glycoprotein complex	Cellular Component	TAS (7937874)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0006936	muscle contraction	Biological Process	TAS (8069911)
GO:0007517	muscle development	Biological Process	TAS (7663524)