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Gene Information
Gene ID:6442
Symbol:SGCA
Full Name:sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
Alias:50-DAG|A2|ADL|DAG2|DMDA2|LGMD2D|SCARMD1|adhalin
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17q21
Physical Location:45598389-45608287 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.463412
Note:"Class I, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000023.1NP_000014.1NC_000017.9 range: 45598389..45608287
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0016012sarcoglycan complexCellular ComponentIEA
GO:0016010dystrophin-associated glycoprotein complexCellular ComponentTAS (7937874)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0006936muscle contractionBiological ProcessTAS (8069911)
GO:0007517muscle developmentBiological ProcessTAS (7663524)
Other Database Cross Links
NCBI Entrez Gene:6442
HGNC:10805
Ensembl:ENSG00000108823
MIM:600119
HPRD:02525
HuGE Navigator:6442
dbSNP:SGCA
GeneCard:SGCA
AceView:SGCA