ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adcy3

Full Name:

adenylate cyclase 3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

6q14

Physical Location:

27118399-27202274 on NC_005105.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 109 Symbol (Name): ADCY3 (adenylate cyclase 3)

Ortholog Status:

The human GeneID 109 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adcy3
Fold Change:		1.14
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_130779.2	NP_570135.2	NC_005105.2 range: 27118399..27202274

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IDA (12748066)
GO:0045121	membrane raft	Cellular Component	IDA (12748066)
GO:0004016	adenylate cyclase activity	Molecular Function	IDA (2255909)
GO:0005515	protein binding	Molecular Function	ISS
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Molecular Function	IMP (12798295)
GO:0006171	cAMP biosynthetic process	Biological Process	IDA (12798295)
GO:0007143	female meiosis	Biological Process	IEP (12798295)
GO:0007242	intracellular signaling cascade	Biological Process	IDA (12798295)
GO:0007608	sensory perception of smell	Biological Process	IDA (2255909)