ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fzd2

Full Name:

frizzled homolog 2 (Drosophila)

Alias:

Fz-10|Fzd10

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q32.1

Physical Location:

91709221-91711131 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2535 Symbol (Name): FZD2 (frizzled homolog 2 (Drosophila))

Ortholog Status:

The human GeneID 2535 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fzd2
Fold Change:		1.13
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172035.1	NP_742032.1	NC_005109.2 range: 91709221..91711131

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	TAS (12471263)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0042813	Wnt receptor activity	Molecular Function	IDA (12471263)
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0004926	non-G-protein coupled 7TM receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0030855	epithelial cell differentiation	Biological Process	ISS
GO:0030855	epithelial cell differentiation	Biological Process	IEA
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007267	cell-cell signaling	Biological Process	ISS
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	Biological Process	IDA (12471263)
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	IDA (12471263)
GO:0007199	G-protein signaling, coupled to cGMP nucleotide second messenger	Biological Process	IDA (12471263)
GO:0007267	cell-cell signaling	Biological Process	IEA