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Gene Information
Gene ID:64512
Full Name:frizzled homolog 2 (Drosophila)
Organism:Rattus norvegicus (Rat)
Genetic Location:10q32.1
Physical Location:91709221-91711131 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2535    Symbol (Name): FZD2 (frizzled homolog 2 (Drosophila))
Ortholog Status:The human GeneID 2535 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Fzd2
Fold Change:1.13
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_172035.1NP_742032.1NC_005109.2 range: 91709221..91711131
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentTAS (12471263)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0042813Wnt receptor activityMolecular FunctionIDA (12471263)
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004926non-G-protein coupled 7TM receptor activityMolecular FunctionIEA
GO:0004930G-protein coupled receptor activityMolecular FunctionIEA
GO:0030855epithelial cell differentiationBiological ProcessISS
GO:0030855epithelial cell differentiationBiological ProcessIEA
GO:0016055Wnt receptor signaling pathwayBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007267cell-cell signalingBiological ProcessISS
GO:0007223Wnt receptor signaling pathway, calcium modulating pathwayBiological ProcessIDA (12471263)
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessIDA (12471263)
GO:0007199G-protein signaling, coupled to cGMP nucleotide second messengerBiological ProcessIDA (12471263)
GO:0007267cell-cell signalingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:64512