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Gene Information
Gene ID:64514
Symbol:Eif2b1
Full Name:eukaryotic translation initiation factor 2B, subunit 1 alpha
Alias:eIF-2a
Organism:Rattus norvegicus (Rat)
Chromosome:12
Genetic Location:12q15
Physical Location:33138322-33146595 on NC_005111.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1967    Symbol (Name): EIF2B1 (eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa)
Ortholog Status:The human GeneID 1967 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.9181
Original ID2:Eif2b1
Fold Change:1.35
P Value:0.00045
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Eif2b1
Fold Change:1.29
Tissue:Amygdala
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_172029.1NP_742026.1NC_005111.2 range: 33138322..33146595
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005851eukaryotic translation initiation factor 2B complexCellular ComponentISS
GO:0005624membrane fractionCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentIDA (9798914)
GO:0005737cytoplasmCellular ComponentISS
GO:0005850eukaryotic translation initiation factor 2 complexCellular ComponentIDA (3818593)
GO:0005850eukaryotic translation initiation factor 2 complexCellular ComponentTAS (11804848)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentISS
GO:0005624membrane fractionCellular ComponentISS
GO:0003743translation initiation factor activityMolecular FunctionIDA (3818593|9798914)
GO:0019003GDP bindingMolecular FunctionIDA (3818593)
GO:0030234enzyme regulator activityMolecular FunctionIMP (11804848)
GO:0005525GTP bindingMolecular FunctionIMP (3818593)
GO:0003743translation initiation factor activityMolecular FunctionISS
GO:0003743translation initiation factor activityMolecular FunctionISS
GO:0003743translation initiation factor activityMolecular FunctionTAS (11804848)
GO:0005085guanyl-nucleotide exchange factor activityMolecular FunctionISS
GO:0005085guanyl-nucleotide exchange factor activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIDA (9446619)
GO:0005515protein bindingMolecular FunctionIPI
GO:0005515protein bindingMolecular FunctionISS
GO:0044237cellular metabolic processBiological ProcessIEA
GO:0043434response to peptide hormone stimulusBiological ProcessIDA
GO:0032057negative regulation of translational initiation in response to stressBiological ProcessIMP (11463353)
GO:0014003oligodendrocyte developmentBiological ProcessISS
GO:0009749response to glucose stimulusBiological ProcessIDA
GO:0009408response to heatBiological ProcessIDA
GO:0006417regulation of translationBiological ProcessIMP (11500297|11804848)
GO:0006413translational initiationBiological ProcessISS
GO:0006413translational initiationBiological ProcessIDA (3818593)
GO:0006412translationBiological ProcessTAS (9798914)
GO:0006412translationBiological ProcessIDA (3818593)
GO:0051716cellular response to stimulusBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:64514
RGD:620819
Ensembl:ENSRNOG00000001039
dbSNP:Eif2b1