ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

B3gat2

Full Name:

beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)

Organism:

Rattus norvegicus (Rat)

Chromosome:

Gene Type:

protein-coding

Human Ortholog:

GeneID: 135152 Symbol (Name): B3GAT2 (beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S))

Ortholog Status:

The human GeneID 135152 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		B3gat2
Fold Change:		1.14
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	NAS
GO:0016020	membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Molecular Function	IMP (10082676)
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Molecular Function	IDA
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEP
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016051	carbohydrate biosynthetic process	Biological Process	IEP
GO:0016051	carbohydrate biosynthetic process	Biological Process	IMP (10082676)