ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bad

Full Name:

bcl2-associated death promoter

Alias:

MGC72439

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q43

Physical Location:

209617372-209626291 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 572 Symbol (Name): BAD (BCL2-antagonist of cell death)

Ortholog Status:

The human GeneID 572 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.36696
Original ID2:		Bad
Fold Change:		1.14
P Value:		0.0013
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022698.1	NP_073189.1	NC_005100.2 range: 209617372..209626291

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (15120593)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (15120593)
GO:0005515	protein binding	Molecular Function	IPI (11161472\|15120593)
GO:0043422	protein kinase B binding	Molecular Function	IPI (15120593)
GO:0005515	protein binding	Molecular Function	ISS
GO:0030346	protein phosphatase 2B binding	Molecular Function	IPI (15120593)
GO:0045579	positive regulation of B cell differentiation	Biological Process	ISS
GO:0043281	regulation of caspase activity	Biological Process	ISS
GO:0043065	positive regulation of apoptosis	Biological Process	IMP (11161472)
GO:0042981	regulation of apoptosis	Biological Process	ISS
GO:0042593	glucose homeostasis	Biological Process	ISS
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	ISS
GO:0008624	induction of apoptosis by extracellular signals	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	IMP (11161472)
GO:0006915	apoptosis	Biological Process	ISS
GO:0006007	glucose catabolic process	Biological Process	ISS
GO:0045582	positive regulation of T cell differentiation	Biological Process	ISS